Why does reflux happen on medicines that slow stomach emptying?

Slowing how quickly the stomach empties is part of how GLP-1 medicines produce fullness. A consequence is that food and acid sit in the stomach longer, and for some people that makes reflux more likely or worse than before.

General reflux guidance covers meal size and timing, what tends to aggravate it, and not lying down soon after eating. That guidance is written for reflux broadly rather than for people on these medicines, but the mechanism it addresses is the same.

Whether a particular antacid or acid-reducing medicine is suitable alongside something that already slows gastric emptying is a question for a pharmacist or prescriber, not a general page. Persistent reflux, difficulty swallowing or pain on swallowing are reasons to be seen rather than self-manage.